Researchers have developed a new method to counter emergent mutations of Covid-19 and hasten vaccine development to stop the pathogen responsible for killing thousands of people and ruining economies.
Using Artificial Intelligence (AI), the research team at the University of Southern California’s Viterbi School of Engineering developed a method to speed the analysis of vaccines and zero in on the best potential preventive medical therapy.
According to the researchers, the method is easily adaptable to analyze potential mutations of the virus, ensuring the best possible vaccines are quickly identified — solutions that give humans a big advantage over the evolving contagion.
“This AI framework, applied to the specifics of this virus, can provide vaccine candidates within seconds and move them to clinical trials quickly to achieve preventive medical therapies without compromising safety,” said researcher Paul Bogdan from the varsity.
“Moreover, this can be adapted to help us stay ahead of the coronavirus as it mutates around the world,” Bogdan added, in the study published in the journal Scientific Reports.
When applied to SARS-CoV-2 — the virus that causes Covid-19 — the computer model quickly eliminated 95 per cent of the compounds that could’ve possibly treated the pathogen and pinpointed the best options, the study said.
The AI-assisted method predicted 26 potential vaccines that would work against the coronavirus.
From those, the researchers identified the best 11 from which to construct a multi-epitope vaccine, which can attack the spike proteins that the coronavirus uses to bind and penetrate a host cell.
Vaccines target the region — or epitope — of the contagion to disrupt the spike protein, neutralizing the ability of the virus to replicate, the team said.
Moreover, the engineers can construct a new multi-epitope vaccine for a new virus in less than a minute and validate its quality within an hour, they added.
By contrast, current processes to control the virus require growing the pathogen in the lab, deactivating it and injecting the virus that caused a disease. The process is time-consuming and takes more than one year; meanwhile, the disease spreads.
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